Determining if Cavum Septum Pellucidum can be used as a Neuroimaging Biomarker
for Traumatic Brain Injury Severity.
 
   Lead Investigator:    Peter Fonseca
   Institution      :    UCSF
   E-Mail           :    Peter.fonseca@ucsf.edu
   Proposal ID      :    560



   Proposal Description:
   We are interested in how TBI severity influences lasting effects in later life    and dementia. We want to determine if CSP can be an indication of TBI severity.                                                                                                                                                                       We would like to define our population by TBI severity groups using the UDS       Subject Health History form, including healthy controls, patients with            dementia, and patients with mild cognitive impairment (MCI). We will ask if       reportedly more severe TBI are correlated with a higher prevalence of CSP, a      higher grade, and a larger size. If our hypotheses are correct, we would expect                                                                                                                                                                       that larger CSPs are indicative of more severe TBI, creating a potential          objective imaging biomarker for assessing TBI severity. At the least, we would    like to determine if consideration of CSP improves current predictors for TBI     severity.